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Insulin getting assembled into a mature form was the major challenge in commercial insulin production by rDNA technology. How did Eli Nilly found a solution to this problem?

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An American company Eli Lilly in 1983 prepared two DNA sequences corresponding to A and B, chains of human insulin and inserted in plasmids of E, coli to produce insulin chains. Chains A and B were produced separately, extracted and combined by creating disulfide bonds to form human insulin.

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