Since,
We know that last digit of any number can end with 0 only when if that number is a multiple of 10.
Since, last digit of 3n never be 5 or 0 for any natural number n and the last digit of 22n never be 0 for any natural number n.
Hence, last digit of 12n never be 0 for any natural number n.
Hence, 12n can not end with the digit 0 for any natural number n.