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In which phase of the cell cycle does synthesis of histone proteins take place?

(a) Anaphase-I

(b) S-phase

(c) G1-phase

(d) G2-phase

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Answer is : (b) S-phase

Synthesis of the DNA and the histone proteins takes place during the S-phase (synthetic phase) of interphase in cell cycle.

In this phase, the cell synthesises a replica of its genome by the process of DNA replication. Thus, DNA content becomes doubled.

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