During first half of menstrual cycle, the primary follicles in the ovary grow to become a fully mature Graafian follicle and simultaneously the endometrium of uterus regenerates through proliferation. These changes in the ovary and the uterus are induced by changes in the levels of pituitary and ovarian hormones. The secretion of gonadotropins (LH and FSH) increases gradually during the follicular phase and stimulates follicular development as well as secretion of estrogens by the growing follicles.
