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Trace the life-cycle of malarial parasite in the human body when bitten by an infected female Anopheles.

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Plasmodium falciparum is the malarial parasite. 

Life cycle of Plasmodium 

• Plasmodium requires two hosts to complete its life cycle—human and mosquito. 

• The infected female Anopheles mosquito transfers the infectious form of Plasmodium, i.e., sporozoites to the human body by biting. 

• The sporozoites reach the liver cells, where they multiply. 

• This is followed by their attack on red blood cells resulting in their rupture. 

• The ruptured RBCs release a toxin called haemozoin, which is responsible for high recurring fever, chills and shivering. 

• These parasites enter the female Anopheles mosquitoes when they bite an infected person. 

• In the body of mosquitoes, they fertilise and multiply in the stomach wall. 

• Sporozoites are now stored in the salivary gland of mosquito till it is again transferred to human body by a mosquito bite. After entering the human body, all the events are repeated.

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