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What are lysosomal storage diseases ?

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The lysosomal diseases cause accumulation of material awaiting digestion in the lysosomes. The first such disease was identified in 1963 by the Belgain investigator H.G. Hers. It was named glycogen storage disease. The cells of the person with this disease lack the lysosomal enzyme, `alpha`-glycoisdase, which degrades glycogen. As a result, the cells of liver, muscles and other tissues contain large glycogen filled lysosomes. In another lysosomal storage disease, lipids accumulate in the lysosomes due to lack of lipid-degrading enzyme.

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