1. The origin and maintenance of resting potential depends on the original state of no stimulation.
2. Any stimulus or disturbance to the membrane will make the membrane permeable to Na+ ions. This causes rapid influx of Na+ ions.
3. The voltage gated Na+ /K+ channels are unique. They can change the potential difference of the membrane as per the stimulus received and also the gates operate separately and are self closing.
4. During resting potential, both gates are closed and resting potential is maintained.
5. However during depolarization, the Na+ channels open but not the K+ channels. This causes Na+ to rush into the axon and bring about a depolarisation. This condition is called action potential.
6. Extra cellular fluid (ECF) becomes electronegative with respect to the inner membrane which becomes electropositive.
