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Why do children cured by enzyme-replacement therapy for adenosine deaminase dediciency need periodic tratment ?

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The SCID patient ha sa defective gene for the enziyme adenosine deaminsase (ADA) the patient lacks functinal T lyphoclytes in these lymphocyte gene coding for ADA is introduced using retrovirus and these cells are reintroduced in to patients bone marrow these cells are not immortal and therefore the patient requires periodic treatment

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