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In animal husbandry, if two closely related animals are mated for a few generations it results in loss of fertility and vigour. Why is this so?

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The phenomenon of mating closely related animals is called inbreeding. Continued inbreeding for a few generations leads to inbreeding depression which results in loss of fertility and vigour. This is because the recessive alleles tend to get together and express harmful effects in the coming progenies.

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