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Pituitary gland, through termed as master endocrine gland, operates under instructions from hypothalamus , by which this control is kept on pituitary glands.

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(1) Hypothalamus is the controlling centre for pituitary gland,
(2) Hypothalamus secretes releasing factors and inhibiting fac-tors and hence regulate the secretions of hypophysis. E.g . Adrenocor-ticotropin hormone releasing factor or CRF , Thyrotropin releasing factor or TSHRF , GHRF and GHRIF, i.e, Growth hormone releasing and release inhibiting factor, etc.
(3) Hypothalamus forms the hypothalamo-hypophysical axis through which transportation of neurohormones take place.
(4) Hormones like vasopressin and oxytocin are secreted by neurosecretory cells of hypothalamus.
(5) Hypothalamus can register the internal changes in the body as it is a part of diencephalon and thus it accordingly brings about coorination in the body through endocrine system.

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