f(x) = x2 + 16/x2
∴ the roots of f'(x) = 0 are x1 = 2 and x2 = -2.
∴ by the second derivative test, f has minimum at x = 2 and minimum value of f at x = 2
∴ by the second derivative test, f has minimum at x = -2 and minimum value of f at x = -2
Hence, the function f has minimum value 8 at x = ± 2.