When an infected female Anopheles mosquito bites a person, the sporozoites are injected into the body. They reach the liver cells through blood. The paraite reproduces asexually in the liver cells and by the bursting of liver cells, new cells are released into the blood. They enter the red blood cells and reproduce asexually, by bursting the red blood cells, the cycles of fever, chill and shivering occur.
The released parasites infect new red blood cells, some continue the asexual reproduction and cause the cycles of fever. The sexual stage of the parasite leads to formation of gametocytes in the RBCs, which are picked by the Anopheles mosquito along with the blood meal.
