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Name any two databases important in bioinformatics. Mention the type of information which may be obtained from these databases.

 OR

 Suggest two possible ways for analyzing a given sequence using bioinformatics.

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Database Information Available
EMBL(European Molecular
Biology Laboratory)
Nucleotide sequence
Nucleotide sequence Annotated protein sequence
PDB (Protein Database) Three dimensional structure of proteins
Ribosomal RNA database r RNA subunit sequences
PALI database Phylogenetic analysis and alignment of protein

 

OR

1. Processing raw information: The experimentally determined sequence (raw information) is processed using bioinformatics tools into genes, the proteins encoded and their function, the regulatory sequences, and inferring phylogenetic relationships. 

2. Genes: Gene prediction can be done by using computer programs like Gene Mark for bacterial genomes and GENSCAN for eukaryotes. 

3. Proteins: Protein sequences can be inferred from the predicted genes by using simple computer programs. 

4. Regulatory sequences: Regulatory sequences can also be identified and analysed by using bioinformatics tools. 

5. Inferring phylogenetic relationships: Information regarding the relationships between organisms can be obtained by aligning multiple sequences, calculating evolutionary distance and constructing phylogenetic trees. 

6. Making a Discovery: Using the bioinformatics tools and databases, the functions of unknown genes can be predicted.

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