Let P(x, y) be any point on the required locus. P is equidistant from A(- 5, 2) and B(4, 1).
∴ PA = PB
∴ PA2 = PB2
∴ (x + 5)2 + (y – 2)2 = (x – 4)2 + (y – 1)2
∴ x2 + 10x + 25 + y2 — 4y + 4 = x2 – 8x + 16 + y2 – 2y + 1
∴ 10x – 4y + 29 = -8x – 2y + 17
∴ 18x – 2y + 12 = 0
∴ 9x – y + 6 = 0
The required equation of locus is 9x -y + 6 = 0.