Question

Microtubule depolymerising drug such as colchicine is expected to

(a) inhibit spindle formation during mitosis

(b) inhibit cytokinesis

(c) allow mitosis beyond metaphase

(d) induce formation of multiple contractile rings.

Answer 1

The correct option is: (a) inhibit spindle formation during mitosis

Explanation:

Colchicine is extracted from the corm of the autumn crocus (Colchicum autmnale). lt inhibits metaphase and also inhibits the formation of mitotic spindles because it prevents assembly of microtubules. So, they are called mitotic poison. It does not inhibit chromosome replication and so shows doubling.