Question

Predictions solely based on hydrophobicity profiles have lowest error rates.

(a) True

(b) False

The question was posed to me in quiz.

Origin of the question is Secondary Structure Prediction for Transmembrane Proteins topic in division Secondary Structure Prediction of Bioinformatics

Answer 1

Right answer is (b) False

Best explanation: Predictions solely based on hydrophobicity profiles have high error rates. As with the third-generation predictions for globular proteins, applying evolutionary information with the help of neural networks or HMMs can improve the prediction accuracy significantly.