Question

Because different prediction programs have different levels of sensitivity and specificity, it makes sense to combine results of multiple programs based on consensus. This idea has prompted development of consensus-based algorithms.

(a) True

(b) False

The question was asked in an international level competition.

The above asked question is from Gene Prediction in Eukaryotes topic in section Gene and Promoter Prediction of Bioinformatics

Answer 1

Correct answer is (a) True

For explanation: These programs work by retaining common predictions agreed by most programs and removing inconsistent predictions. Such an integrated approach may improve the specificity by correcting the false positives and the problem of over prediction. However, since this procedure punishes novel predictions, it may lead to lowered sensitivity and missed predictions.