If the number 4n, for any n, were to end with the digit zero, then it would be divisible by 5. That is, the prime factorisation of 4n would contain the prime 5. This is not possible because 4n = (2)2n; so the only prime in the factorisation of 4n is 2. So, the uniqueness of the Fundamental Theorem of Arithmetic guarantees that there are no other primes in the factorisation of 4n. So, there is no natural number n for which 4n ends with the digit zero.
You have already learnt how to find the HCF and LCM of two positive integers using the Fundamental Theorem of Arithmetic in earlier classes, without realising it! This method is also called the prime factorisation method. Let us recall this method through an example.