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How did the global transfer of disease in the pre-modern world help in the colonization of the Americans ?

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(i) America was not conquered and colonized by Europeans with the help of superior firepower alone.
(ii) Germs, such as those of smallpox were a helpful to a great extent.
(iii) Americans had no immunity against them as a result of long isolation. Once introduced, the germs spread deep into the continent decimating whole communities and paving way for Conquest.

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