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How many calcium ions diffuse across a pre-synaptic membrane at a time?​

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1. Calcium (Ca2+)is a vital element in the process of neurotransmitter release; when Ca2+channels are blocked, neurotransmitter release is inhibited.

2. These consist of multi-protein complexes that tether the synaptic vesicle to the presynaptic membrane and contain high concentrations of voltage-gated calcium channels.

3. This leads to brisk calcium influx in response to axon terminal depolarization, since the concentration of calcium is 10,000 times higher in the extracellular fluid.

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