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The predominant form of histamine present in human blood is (pKa, Histidine = 6.0)

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The predominant form of histamine present in human blood is (pKa, Histidine = 6.0)

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Blood pH = 7.3
1st pKa of N = 9.9
2nd pKa of N = 5.88
Histamine : It has three nitrogen
In normal physiological condition it exist as monoprotonated and aliphatic nitrogen is most basic so it will be protonated.

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Answer: (3)

Structure of Histamine

Blood is slightly basic in nature (7.35 pH) approx. At this pH terminal NH2 will get protonated due to more basic nature. Predominant structure of Histamine is

Structure of Histamine

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