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In a variant of chymotrypsin, Asp 102 is replaced by Glu 102. Do you expect the enzyme to retain activity? Schematically indicate the role of amino acid residues participating in catalysis.

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Negatively charged Asp 102 partially borrow hydrogen ion from His-57. His-57 attracts hydrogen ion from adjacent Ser 195 

Serine 195 gets negative charge. 

Serine 195 makes a nucleophilic attack on the protein substrate.

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