Fewpal
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Cancer cells may become resistant to amethopterin by

(A) Developing mechanisms to destroy amethopterin

(B) Amplification of dihydrofolate reducatse gene

(C) Mutation in the dihydrofolate reductase gene so that the enzyme is no longer inhibited by amethopterin

(D) Developing alternate pathway of thymidylate synthesis

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(B) Amplification of dihydrofolate reducatse gene

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