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Systemic clearance (CLs) is related with: a) Only the concentration of substances in plasma

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Systemic clearance (CLs) is related with: 

a) Only the concentration of substances in plasma 

b) Only the elimination rate constant 

c) Volume of distribution, half life and elimination rate constant 

d) Bio availability and half life 

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c) Volume of distribution, half life and elimination rate constant 

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