Choose the correct statement about topical NSAID preparations:
A. They produce high drug levels in the blood by avoiding hepatic first pass metabolism
B. They produce high drug levels in the subjacent muscle and joint tissues upto a depth/distance of 10 cm from the site of application
C. They elicit symptomatic relief in soft tissue rheumatism mainly by a strong placebo effect
D. Interindividual variability in clinical response to these preparations is minimal