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Choose the correct statement about topical NSAID preparations: 

A. They produce high drug levels in the blood by avoiding hepatic first pass metabolism 

B. They produce high drug levels in the subjacent muscle and joint tissues upto a depth/distance of 10 cm from the site of application 

C. They elicit symptomatic relief in soft tissue rheumatism mainly by a strong placebo effect 

D. Interindividual variability in clinical response to these preparations is minimal

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C. They elicit symptomatic relief in soft tissue rheumatism mainly by a strong placebo effect 

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