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Choose the correct statement about theophylline:

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Choose the correct statement about theophylline: 

A. Its use in asthma has declined because of narrow safety margin 

B. Its dose needs to be reduced in smokers 

C. It acts by increasing the formation of cAMP 

D. Its plasma halflife is longer in children compared to that in adults

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A. Its use in asthma has declined because of narrow safety margin

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