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The following measure can minimise pituitary-adrenal suppression during long-term corticosteroid therapy: 

A. Use of betamethasone in place of prednisolone 

B. Use of prednisolone on alternate days 

C. Division of the daily dose in three equal 8 hourly doses 

D. Administration of the total daily dose at bed time

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B. Use of prednisolone on alternate days

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