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FSH and LH

FSH and LH in Females and Males




stimulates ovary to produce steroids

ovary will produce estradiol during follicular phase and progesterone during luteal phase

surge at midcycle, with LH, triggers ovulation

stimulates ovary to produce steoroids

surge at midcycle triggers ovulation

remember, luteinizing hormone turns the follicle into the corpeus luteum by triggering ovulation


stimulates Sertoli cells to produce androgen-binding protein (ABP), thereby stimulating spermatogenesis

FSH also stimulates Sertoli cells to produce inhibin, which provides negative feedback to the anterior pituitary to decrease FSH secretion

stimulates Leydig cells to produce testosterone

testosterone provides negative feedback to anterior pituitary and hypothalamus

In the female:


Negative feedback:

occurs during follicular phases when estrogen levels are still low.

Postive feedback:

occurs at high concentrations near the end of the follicular phase, estrogen becomes a positive inducer of the anterior pituitary

positive feedback triggers the anterior pituitary to release more FSH and LH

more FSH and LH cause the ovary to produce more estrogen

the ensuing LH surge is responsible for ovulation


stimulate secretory and vascular activity of the endometrium, preparing for implantation of an embryo

secreted by the corpus luteum, after ovulation

when corpus luteum regresses, progresterone levels fall

new vasculature in endometrium regresses and the tissue sloughs off.

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