Topoisomerase : Cause single strand breaks and religation. Helicase: Unwounds a portion of the DNA Double Helix.
RNA Primase : Attaches RNA primers to the replicating strands.
DNA Polymerase delta (δ) : Binds to the 5′ – 3′ strand in order to bring nucleotides and synthesise the daughter leading strand.
DNA Polymerase epsilon (a): Binds to the 3′ – 5′ strand in order to synthesise discontinuous segments starting from different RNA primers.
Exonuclease (DNA Polymerase I): Identifies and removes the RNA Primers.
DNA Ligase : Adds phosphate in the remaining gaps of the phosphate – sugar backbone.
Nucleases : Remove wrong nucleotides from the daughter strand.
