During unfavorable conditions (increase or decrease in temperature and scarcity of food) Amoeba withdraws its pseudopodia and secretes a three-layered, protective, chitinous cyst wall around it and becomes inactive. This phenomenon is called encystment. When conditions become favourable, the encysted Amoeba divides by multiple fission and produces many minute amoebae called pseudopodiospore or amoebulae.
The cyst wall absorbs water and breaks off liberating the young pseudopodiospores, each with a fine pseudopodia. They feed and grow rapidly to lead an independent life.