A specialised respiratory center present in the medulla oblongata of the hind brain called respiratory rhythm center is responsible for this regulation. Pneumotaxic centre present in ponsvaroli region of the brain moderates the function of the respiratory rhythm centre to ensure normal breathing.
The chemosensitive area found close to the rhythm centre is highly sensitive to CO2 and H+ . And H+ are eliminated out by respiratory process. Receptors associated with the aortic arch and carotid artery send necessary signals to the rhythm center for remedial action. The role of O2 is insignificant in the regulation of respiratory rhythm.
