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The Endoplasmic Reticulum membrane is similar in structure to the: 

A. Nuclear membrane 

B. Plasma membrane

C. Mitochondrial membrane 

D. Membranes in plastids

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B. Plasma Membrane

Just as the plasma membrane separates the cellular cytoplasm from the outside, the membrane of endoplasmic reticulum separates the inner content of the ER from the cellular cytoplasm.

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