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Thalassemic patients produce excess alpha or beta subunits of haemoglobin leading to impaired oxygen-binding capacity by their erythrocytes. How can the subunit produced in excess be determined?

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Normal and thallasaemic erythrocytes obtained and their lysates analysed 

Protein fingerprinting/2-D gel electrophoresis/MALDI-TOF/SDS-PAGE can identify if α or β chain is absent.

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