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Which of the following is/are required for full expression of the lac operon?

(a) Lactose

(b) Allolactose

(c) Lactose and cAMP

(d) Allolactose and cAMP

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Answer is : (d) Allolactose and cAMP

The lac operon of E.coli contains genes involved in lactose metabolism.

Two regulators turn the operon ‘on’ and ‘off’ in response to lactose and glucose levels, the lac repressor and Catabolite Activator Protein (CAP). The lac repressor senses lactose through allolactose and stops acting as repressor. CAP activates transcription of operon sensing low glucose levels through cAMP.

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