A region is an area of a country or any part of the world with same common features. Thus, regions are differentiated on the basis of physical or man-made or socio-cultural factors.
For example, Chota Nagpur plateau region has plateau relief. Himalayan mountain region has mountainous relief. The desert region of Rajasthan has shortage of rainfall and very high temperature. Northern plain region has plain relief, fertile soil and moderate climate.
The region may be differentiated on the basis of man-made factors like political factors such as administrative boundaries or political boundaries.
For example, Uttar Pradesh and Punjab are two different regions because they have different political boundaries and government bodies.
The region may be differentiated on the basis of socio-cultural factors such as language, religion or ethnicity.
For example, in Mumbai there is an area, where people speaking Gujarati language live in one region. The Middle East countries form one region where people of Muslim religion stay together.
Thus, regions are differentiated on the basis of various factors.