Question

Write a brief note on Monogenic disorders.

Answer 1

• Disorders occurring due to mutation in any single gene into a defective one are called monogenic disorders. Approximately 4000 disorders of this type are now known.
• Due to abnormal genes, their products are either produced in insufficient quantity or not produced at all.
• It causes abnormal metabolism and may lead to death at a tender age.
• Examples of monogenic disorders are Hutchinson’s disease, Tay-Sachs disease, galactosaemia, phenylketonuria, sickle cell anaemia, cyctic fibrosis, albinism, haemophilia, night blindness etc.