Blood can never be synthesized artificially. There is no substitute for natural blood. Every healthy person possesses about 5 litres of blood in his or her body. In case of haemorrhage i.e. blood loss, the blood volume may reduce which can result into threat to life. Moreover, the loss of blood should be immediately taken care of, otherwise it may cost the life.
Therefore blood transfusion is very crucial in case of victims of accidents, patients of surgeries or mothers who suffer from blood loss during childbirth (parturition). Some diseases such as thalassemia, blood cancer, etc. also need regular transfusions. Therefore, blood is always needed in many such conditions. Blood donation is only option for such transfusions.