Question

The most striking example of point mutation is found in a disease called 

(a) thalassemia 

(b) night blindness 

(c) Down's syndrome 

(d) sickle-cell anaemia

Answer 1

Correct option (d) sickle-cell anaemia

Explanation

Sickie-cell anaemia is an example of point mutation. It is a genetic disease reported from negroes due to a molecular mutation of gene Hb^A on chromosome 11 which produces β-chain of adult haemoglobin. 

In this disease nucleotide triplet CTC is changed to CAC, these changes takes place at a particular point of chromosome, so they are called as point mutation.