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When McLeod, Avery and McCarty experimented to establish the chemical nature of the 'Transforming Principle', which of the following statement/s helped them reach their conclusion? 

1: Proteases did not affect transformation 

2: DNases did not affect transformation. 

3: RNases did not affect transformation. 

4: The R strain could synthesise the polysaccharide coat. 

A. only 1 and 2 

B. only 1 and 3 

C. only 1, 3 and 4 

D. only 2,3 and 4

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