Question

Among the given compounds, the most susceptible to nucleophilic attack at the carbonyl group is

(a) CH₃COOCH₃ 

(b) CH₃CONH₂

(c) CH₃COOCOCH₃ 

(d) CH₃COCl

Answer 1

The correct option is: (d) CH₃COCl

Explanation:

CH₃COCl is most susceptible to nucleophilic attack. The susceptibility of a substrate towards nucleophilic attack depends on how good a leaving group is attached to it. Cl^- is a weak base and therefore a good leaving group.