Question

______ molecules can simply be identified based on their sequence similarity with already-known sequences.

(a) Larger, less conserved

(b) Larger, highly conserved

(c) smaller, highly conserved

(d) shorter, highly conserved

Answer 1

Correct option is (b) Larger, highly conserved

The best explanation: For smaller sequences with more sequence variation, this method does not work. A number of methods for finding small RNA genes have been described and are available on the Web. A major problem with these methods in searches of large genomes is that a small false positive rate becomes quite unacceptable because there are so many false positives to check out.