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Fischer’s ‘lock and key’ model of the enzyme action implies that 

(A) The active site is complementary in shape to that of substance only after interaction. 

(B) The active site is complementary in shape to that of substance 

(C) Substrates change conformation prior to active site interaction 

(D) The active site is flexible and adjusts to substrate

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(B) The active site is complementary in shape to that of substance

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