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Select the antihistaminic which blocks cardiac K+ channels when given in high doses or along with drugs that inhibit CYP3A4 isoenzyme:

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Select the antihistaminic which blocks cardiac K+ channels when given in high doses or along with drugs that inhibit CYP3A4 isoenzyme: 

A. Chlorpheniramine 

B. Promethazine 

C. Astemizole 

D. Loratadine

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C.  Astemizole

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