Difficulties in copying manuscripts were:
(i) Copying manuscript was an expensive business.
(ii) It was laborious and time-consuming.
(iii) Manuscripts themselves were fragile, awkward to handle and could not be easily carried around or read easily.
Use of printing press:
(i) It enable people to produce books at greater speed.
(ii) The production of books in large number created a new culture of reading and enlarged the number set up of readers.